Body inflammation and obesity: How it brings about weight gain
A common theme that links many diseases and chronic illness is uncontrolled cellular inflammation. It is a factor in diseases including cardiovascular disease, diabetes, cancer, arthritis and many autoimmune-related conditions. Obesity has recently been added to this group of diseases as it is now known to present a low grade inflammatory response within many of the body’s tissues, which cause deleterious effects, leading to the development of cardiovascular and metabolic disease. It is well known that being overweight is detrimental to one’s health, but until recently the known mechanisms were limited. Scientists over the last decade have started to unravel the mystery of why body inflammation and obesity leads to premature death. Although there is still much to learn, it is valuable to comprehend the known effects of chronic inflammation, as the prevalence of obesity continues to be a rising problem among the American population, particularly in children.
Body inflammation and obesity: Inflammation and obesity
Inflammation is, by design, a protective response leading to the repair of tissue. Speaking to the experts at AWAREmed health and wellness resource center under the leadership of doctor Dalal Akoury MD it is evident that when inflammation becomes chronic, as is the case with obesity, chemical mediators, derived from different cellular activities, change in dynamics causing a progressive state of decline. Fat cells are now considered an immune organ that secretes numerous immune modulating chemicals. Visceral fat, in particular, is associated with the low grade inflammation that seems to be a contributing pathologic feature for metabolic disease through insulin resistance and the promotion of atherosclerotic build-up in circulatory vessels.
When high levels of visceral fat are combined with physical inactivity, over nutrition, and advancement in age, the effect becomes more pronounced. Visceral fat is highly metabolic and contributes to cytokine hyperactivity. Adipokines secreted from fat tissue influence the metabolic process and contribute to proper function. The consequent low grade inflammation associated with obesity causes disturbance in the secretion and function of adipokines. Research has identified changes in adiponectin, leptin, and resistin that exhibit harmful effects upon the body in obese individuals.
Leptin regulates energy metabolism and balance in conjunction with the brain’s hypothalamus. Leptin is currently being touted as having cardio-protective benefits among its others roles in metabolism Leptin concentrations adjust in response to obesity and contribute to insulin resistance.
The changes in leptin concentration have also been recognized as a risk factor for coronary heart disease. Likewise increased resistin concentrations correlate with obesity related inflammation and may be associated with the initiation and progression of atherosclerotic lesions. Resistin also promotes insulin resistance, although the actual mechanism is not known.
Insulin resistance due to adipokine dysfunction is further influenced by free fatty acids liberated directly into the liver from visceral fat tissue. Visceral fat releases chemicals and fatty acids into the portal system where they act on the connecting organs. The portal circulation system is a specialized network of blood vessels that connect the visceral organs to the liver.
The excess fat in portal circulation has detrimental effects on insulin action, which is worsened by sympathetic hyperactivity in response to obesity. Sympathetic hyperactivity causes heightened lypolytic action resulting in excess free fatty acids in the blood. These actions combined with beta cell hypersecretion and reduced insulin clearance resulting in hyperinsulemia, lead to early stage diabetes. This explains why body inflammation and obesity must not be given room to thrive in one’s life. You can seek for more professional information by scheduling an appointment with doctor Akoury today and your life will be transformed positively.
Body inflammation and obesity: How it brings about weight gain
http://www.I-AM-I.com/wp-admin
