For patients suffering liver failures, nothing has helped more than Allogeneic liver transplantation. Unfortunately, the number of liver donors who are more than willing to help is decreasing. It is, therefore important to find another alternative approach to the problem. Hepatocytes transplantation from an adult as well as the foetal liver isn’t quite of a choice simply because the kind of stem cells derived here are currently limited to the human liver.
There have been recent claims that the hepatocyte lineage cells sources have proven quite useful in cell therapy. There are claims that the bone marrow, as well as embryonic stem cells, have the ability to differentiate to form several multi-lineage cells that include hepatocytes found in vitro as well as video models.
Unfortunately, it has also been realised that application of the procedure that includes obtaining embryonic cells from the fertilised eggs in humans has some potential health hazards in several countries. Use of the cells from the human bone marrow is also discouraged due to a limited number of healthy and willing donors.
According to findings, the blood from the umbilical cord has some ability to produce cells needed for treatment of the liver injury. Use of the blood from umbilical cord will also apply to clinical procedures involved in the cell transplantation. Just like embryonic and bone marrow stem cells, this process will be used to treat several liver failures in humans.
The blood from the human umbilical cord is quite beneficial to cell transplantation procedures simply because the new cells, unlike the adult cells, are immature. The transplantation makes it easier to exploit their advantageous nature to derive a good number of fully functional hepatocytes or hepatic stem cells needed to suffice the increasing number of liver failure in people. Transplantation will also help suffice the limited number of healthy embryonic stem cell donors.
A larger scale of hepatic stem cell transplantation is needed to help reduce the number of liver injuries affecting many people around the world. Unfortunately, the source of these vital cells is proving deficient. There is, however, some hope that the ability of the immature cells to suffice the requirements for allogeneic liver transplantation will save the situation.
According to recent reports, the stem cells that are obtained from the blood of an umbilical cord can repopulate bone marrow. However, it is not clear whether the same cells can work as mature hepatocytes needed for treatment of the liver injury.
The bottom line
Liver failure results from some chronic hepatic complications that may lead to several pathogenic processes including fibrosis, inflammation and necrosis of hepatocyte. If not dealt with in time, liver failure may result in death. Stem cell therapy for liver injury has brought back the hope of addressing the problem. However, a few debates are revolving around the shortage of healthy donors which influences the need to come up with new therapeutic strategies. According to recent studies, stem cell therapy has proven to help improve the functionality if hepatocytes as well as reduce the effects of liver injury such as inflammation and the rest. But this will only work if the limit of obtaining the stem cells needed for liver injury is eliminated.
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